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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1841–1848. doi: 10.1158/1055-9965.EPI-09-0197

Table 3.

Risk of glioma, glioblastoma and meningioma with cumulative exposure to lead by genotype for single nucleotide polymorphisms in genes related to oxidative stress in the NCI Brain Tumor Study*

Continuous Cumulative Lead (OR/100 μg/m3-y)
Glioma Glioblastoma† Meningioma
Homozygous
wildtype		 Heterozygous/
Homozygous
variant		 Homozygous
wildtype		 Heterozygous/
Homozygous
variant		 Homozygous
wildtype		 Heterozygous/
Homozygous
variant
Gene rs# OR (95% CI) OR (95% CI) p-int OR (95% CI) OR (95% CI) p-int OR (95% CI) OR (95% CI) p-int
CAT rs769214 1.1 (0.9, 1.2) 0.9 (0.8, 1.0) 0.1 1.1 (1.0, 1.3) 1.0 (0.9, 1.1) 0.1 1.3 (1.1, 1.6) 1.0 (0.9, 1.1) 0.003
CAT rs1001179 0.9 (0.8, 1.0) 1.0 (0.9, 1.2) 0.3 1.0 (0.9, 1.1) 1.1 (1.0, 1.3) 0.05 1.1 (1.0, 1.1) 1.2 (1.0, 1.4) 0.4
GPX1 rs1050450‡ 0.9 (0.8, 1.0) 1.1 (1.0, 1.3) 0.007 0.9 (0.8, 1.1) 1.3 (1.1, 1.5) 0.0004§ 0.9 (0.7, 1.2) 1.4 (1.1, 1.8) 0.0002§
LPO rs8178407 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.7 1.1 (0.9, 1.2) 1.0 (0.9, 1.1) 0.4 0.04 (0.0004, 3.5) 1.1 (1.0, 1.1) 0.002
MPO rs4401102 1.1 (0.9, 1.2) 0.9 (0.8, 1.1) 0.2 1.1 (0.9, 1.3) 0.9 (0.8, 1.1) 0.09 0.4 (0.1, 1.6) 1.1 (1.0, 1.1) 0.02
NCF2 rs11588654 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.7 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.8 1.3 (1.0, 1.6) 1.0 (0.9, 1.1) 0.03
NCF4 rs2075938 1.0 (0.8, 1.1) 1.0 (0.9, 1.1) 0.7 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.9 1.2 (1.0, 1.3) 0.9 (0.6, 1.4) 0.02
NCF4 rs5756381 1.0 (0.8, 1.1) 1.0 (0.9, 1.1) 0.8 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.8 1.2 (1.0, 1.3) 0.9 (0.6, 1.4) 0.02
NCF4 rs8137602 1.0 (0.9, 1.1) 0.9 (0.8, 1.1) 0.4 1.0 (0.9, 1.2) 0.9 (0.7, 1.2) 0.4 1.1 (1.0, 1.3) 0.4 (0.03, 4.7) 0.02
NOS1 rs483589 1.0 (0.9, 1.1) 1.0 (0.9, 1.1) 0.6 1.0 (0.8, 1.1) 1.1 (0.9, 1.3) 0.3 0.6 (0.2, 1.5) 1.2 (1.0, 1.3) 0.003
NOS1 rs545654 0.7 (0.5, 1.1) 1.0 (0.9, 1.1) 0.09 0.5 (0.2, 1.2) 1.0 (0.9, 1.1) 0.02 1.0 (0.8, 1.4) 1.1 (1.0, 1.1) 0.9
NOS1 rs816293 0.9 (0.8, 1.1) 1.0 (0.9, 1.2) 0.2 1.0 (0.8, 1.1) 1.1 (0.9, 1.3) 0.2 0.9 (0.7, 1.2) 1.2 (1.0, 1.3) 0.02
NOS1 rs1123425 1.1 (0.9, 1.2) 0.9 (0.8, 1.1) 0.1 1.1 (0.9, 1.3) 1.0 (0.8, 1.1) 0.2 1.2 (1.0, 1.4) 1.0 (0.9, 1.1) 0.05
NOS1 rs1353939 1.0 (0.9, 1.2) 0.9 (0.8, 1.1) 0.2 1.1 (0.9, 1.2) 1.0 (0.8, 1.1) 0.3 1.1 (1.0, 1.3) 1.0 (0.8, 1.2) 0.04
NOS1 rs2291908 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.4 1.1 (0.9, 1.3) 1.0 (0.9, 1.1) 0.3 1.1 (1.0, 1.3) 1.0 (0.9, 1.1) 0.05
NOS1 rs4767535 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.9 1.0 (0.8, 1.3) 1.0 (0.9, 1.1) 0.9 1.2 (1.0, 1.5) 1.0 (0.9, 1.1) 0.05
NOS1 rs6490121 1.0 (0.8, 1.1) 1.0 (0.9, 1.1) 0.9 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.6 0.6 (0.2, 1.5) 1.1 (1.0, 1.1) 0.05
NOS1 rs7298903 1.0 (0.9, 1.1) 0.7 (0.5, 1.1) 0.05 1.0 (0.9, 1.1) 0.8 (0.6, 1.2) 0.3 1.1 (1.0, 1.1) 1.1 (0.9, 1.4) 0.5
NOS2A rs944725 1.1 (0.9, 1.3) 1.0 (0.9, 1.1) 0.2 1.1 (0.9, 1.4) 1.0 (0.9, 1.1) 0.2 1.3 (1.0, 1.6) 1.0 (0.9, 1.1) 0.03
NOS2A rs4795067 1.1 (0.9, 1.2) 1.0 (0.9, 1.1) 0.3 1.1 (1.0, 1.3) 0.9 (0.8, 1.1) 0.05 1.2 (1.0, 1.6) 1.0 (0.9, 1.1) 0.02
NOS2A rs2297516 0.9 (0.7, 1.1) 1.1 (0.9, 1.2) 0.05 0.9 (0.8, 1.1) 1.1 (0.9, 1.3) 0.2 1.0 (0.9, 1.1) 1.1 (0.9, 1.2) 0.7
NOS2A rs2779252 1.0 (0.9, 1.1) 0.9 (0.8, 1.1) 0.5 1.0 (0.9, 1.2) 1.0 (0.8, 1.1) 0.7 1.1 (1.0, 1.3) 0.2 (0.001, 36.1) 0.03
NOS2A rs8072199 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.9 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.9 0.1 (0.005, 3.7) 1.1 (1.0, 1.1) 0.03
NOS3 rs1799983 0.9 (0.7, 1.1) 1.0 (0.9, 1.1) 0.1 0.9 (0.7, 1.1) 1.1 (1.0, 1.2) 0.04 1.1 (1.0, 1.2) 1.1 (1.0, 1.2) 0.4
NOS3 rs4496877 1.0 (0.8, 1.3) 1.0 (0.9, 1.1) 0.6 1.2 (0.9, 1.5) 1.0 (0.9, 1.1) 0.1 1.3 (1.0, 1.8) 1.0 (1.0, 1.1) 0.02
NOS3 rs12703107 0.8 (0.7, 1.0) 1.0 (0.9, 1.1) 0.04 0.7 (0.6, 1.0) 1.0 (0.9, 1.1) 0.007 1.1 (0.9, 1.2) 1.0 (0.9, 1.1) 0.6
RAC1 rs836554 1.0 (0.9, 1.1) 1.0 (0.9, 1.1) 0.7 1.1 (0.9, 1.2) 1.0 (0.8, 1.1) 0.3 1.2 (1.0, 1.4) 0.9 (0.7, 1.2) 0.01
RAC1 rs6463554 1.0 (0.9, 1.1) 1.0 (0.9, 1.1) 0.8 1.0 (0.9, 1.2) 1.0 (0.8, 1.1) 0.5 1.2 (1.0, 1.3) 0.9 (0.6, 1.3) 0.01
RAC1 rs3729790 1.0 (0.9, 1.1) 0.9 (0.7, 1.1) 0.2 1.0 (0.9, 1.1) 0.8 (0.6, 1.1) 0.2 1.0 (0.9, 1.1) 1.2 (1.0, 1.5) 0.04
RAC2 rs6572 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.7 1.1 (0.9, 1.3) 1.0 (0.9, 1.1) 0.3 1.2 (1.0, 1.3) 1.0 (0.9, 1.1) 0.04
RAC2 rs1476002 1.0 (0.9, 1.1) 1.0 (0.9, 1.1) 0.6 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.6 1.2 (1.0, 1.3) 0.9 (0.7, 1.3) 0.02
RAC2 rs2239774 1.1 (1.0, 1.2) 0.6 (0.4, 0.9) 0.0006 1.1 (1.0, 1.3) 0.3 (0.08, 1.2) 0.0002§ 1.1 (1.0, 1.3) 1.0 (0.9, 1.1) 0.1
RAC2 rs2239775 1.0 (0.9, 1.1) 1.0 (0.9, 1.1) 0.8 1.0 (0.8, 1.1) 1.0 (0.9, 1.1) 0.7 1.2 (1.0, 1.4) 0.8 (0.4, 1.5) 0.005
RAC2 rs4820274 1.0 (0.9, 1.1) 0.8 (0.6, 1.1) 0.2 1.0 (0.9, 1.1) 0.2 (0.02, 1.1) 0.002 1.1 (1.0, 1.1) 1.3 (0.9, 2.0) 0.3
RAC2 rs4821609 1.0 (0.8, 1.1) 1.0 (0.9, 1.1) 0.8 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.9 1.2 (1.0, 1.3) 0.9 (0.7, 1.3) 0.02
RAC2 rs9607432 1.0 (0.9, 1.1) 0.6 (0.4, 1.0) 0.04 1.0 (0.9, 1.1) 0.2 (0.03, 1.3) 0.005 1.1 (1.0, 1.1) 1.3 (0.9, 2.0 0.3
SOD1 rs202445 0.9 (0.8, 1.1) 1.1 (0.9, 1.3) 0.1 0.9 (0.8, 1.1) 1.2 (1.0, 1.4) 0.03 1.0 (0.9, 1.1) 1.2 (1.0, 1.5) 0.2
SOD2 rs4880 0.9 (0.8, 1.1) 1.0 (0.9, 1.1) 0.1 0.8 (0.6, 1.1) 1.1 (1.0, 1.2) 0.02 1.1 (1.0, 1.2) 1.1 (0.9, 1.3) 0.7
SOD2 rs5746136 1.0 (0.9, 1.1) 0.9 (0.8, 1.1) 0.4 1.0 (0.9, 1.1) 0.9 (0.8, 1.1) 0.3 0.9 (0.5, 1.4) 1.2 (1.0, 1.3) 0.02
SOD2 rs5746151 1.0 (0.9, 1.1) 1.3 (0.7, 2.3) 0.4 1.0 (0.9, 1.1) 0.9 (0.4, 1.9) 0.8 1.0 (0.9, 1.1) 1.7 (0.8, 3.5) 0.02
SOD3 rs699473‡ 0.9 (0.8, 1.1) 1.0 (0.9, 1.1) 0.1 1.0 (0.9, 1.1) 1.1 (1.0, 1.2) 0.1 0.8 (0.4, 1.3) 1.2 (1.1, 1.3) 0.003
XDH rs7574920 1.0 (0.8, 1.2) 1.0 (0.9, 1.1) 0.9 1.0 (0.8, 1.3) 1.0 (0.9, 1.1) 0.8 1.3 (1.0, 1.6) 0.8 (0.6, 1.2) 0.001§
XDH rs1429376 1.0 (0.9, 1.2) 1.0 (0.9, 1.1) 0.4 1.1 (1.0, 1.3) 0.9 (0.8, 1.1) 0.06 1.2 (1.0, 1.4) 0.9 (0.6, 1.3) 0.005
XDH rs17038412 1.0 (0.9, 1.1) 1.0 (0.8, 1.2) 0.7 1.0 (0.9, 1.1) 1.2 (0.9, 1.5) 0.1 1.1 (1.0, 1.1) 0.3 (0.05, 1.8) 0.03
XDH rs6718606 1.0 (0.9, 1.1) 1.0 (0.9, 1.1) 0.5 1.0 (0.9, 1.2) 1.0 (0.8, 1.1) 0.4 1.1 (1.0, 1.3) 1.0 (0.8, 1.2) 0.04
*

See Table 2 for genotype frequencies and associations with brain tumor types

†

Cases with glioblastoma are a subset of the cases with glioma

‡

GPX1 rs1050450 is highly correlated with rs1800668 (r2 = 0.9); SOD3 rs699473 is highly correlated with rs2284659 (r2 = 0.9)

§

p ≤ 0.05 after adjustment for multiple comparisons