Table 3.
Continuous Cumulative Lead (OR/100 μg/m3-y) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Glioma | Glioblastoma† | Meningioma | ||||||||
Homozygous wildtype |
Heterozygous/ Homozygous variant |
Homozygous wildtype |
Heterozygous/ Homozygous variant |
Homozygous wildtype |
Heterozygous/ Homozygous variant |
|||||
Gene | rs# | OR (95% CI) | OR (95% CI) | p-int | OR (95% CI) | OR (95% CI) | p-int | OR (95% CI) | OR (95% CI) | p-int |
CAT | rs769214 | 1.1 (0.9, 1.2) | 0.9 (0.8, 1.0) | 0.1 | 1.1 (1.0, 1.3) | 1.0 (0.9, 1.1) | 0.1 | 1.3 (1.1, 1.6) | 1.0 (0.9, 1.1) | 0.003 |
CAT | rs1001179 | 0.9 (0.8, 1.0) | 1.0 (0.9, 1.2) | 0.3 | 1.0 (0.9, 1.1) | 1.1 (1.0, 1.3) | 0.05 | 1.1 (1.0, 1.1) | 1.2 (1.0, 1.4) | 0.4 |
GPX1 | rs1050450‡ | 0.9 (0.8, 1.0) | 1.1 (1.0, 1.3) | 0.007 | 0.9 (0.8, 1.1) | 1.3 (1.1, 1.5) | 0.0004§ | 0.9 (0.7, 1.2) | 1.4 (1.1, 1.8) | 0.0002§ |
LPO | rs8178407 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.7 | 1.1 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.4 | 0.04 (0.0004, 3.5) | 1.1 (1.0, 1.1) | 0.002 |
MPO | rs4401102 | 1.1 (0.9, 1.2) | 0.9 (0.8, 1.1) | 0.2 | 1.1 (0.9, 1.3) | 0.9 (0.8, 1.1) | 0.09 | 0.4 (0.1, 1.6) | 1.1 (1.0, 1.1) | 0.02 |
NCF2 | rs11588654 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.7 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.8 | 1.3 (1.0, 1.6) | 1.0 (0.9, 1.1) | 0.03 |
NCF4 | rs2075938 | 1.0 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.7 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.9 | 1.2 (1.0, 1.3) | 0.9 (0.6, 1.4) | 0.02 |
NCF4 | rs5756381 | 1.0 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.8 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.8 | 1.2 (1.0, 1.3) | 0.9 (0.6, 1.4) | 0.02 |
NCF4 | rs8137602 | 1.0 (0.9, 1.1) | 0.9 (0.8, 1.1) | 0.4 | 1.0 (0.9, 1.2) | 0.9 (0.7, 1.2) | 0.4 | 1.1 (1.0, 1.3) | 0.4 (0.03, 4.7) | 0.02 |
NOS1 | rs483589 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 0.6 | 1.0 (0.8, 1.1) | 1.1 (0.9, 1.3) | 0.3 | 0.6 (0.2, 1.5) | 1.2 (1.0, 1.3) | 0.003 |
NOS1 | rs545654 | 0.7 (0.5, 1.1) | 1.0 (0.9, 1.1) | 0.09 | 0.5 (0.2, 1.2) | 1.0 (0.9, 1.1) | 0.02 | 1.0 (0.8, 1.4) | 1.1 (1.0, 1.1) | 0.9 |
NOS1 | rs816293 | 0.9 (0.8, 1.1) | 1.0 (0.9, 1.2) | 0.2 | 1.0 (0.8, 1.1) | 1.1 (0.9, 1.3) | 0.2 | 0.9 (0.7, 1.2) | 1.2 (1.0, 1.3) | 0.02 |
NOS1 | rs1123425 | 1.1 (0.9, 1.2) | 0.9 (0.8, 1.1) | 0.1 | 1.1 (0.9, 1.3) | 1.0 (0.8, 1.1) | 0.2 | 1.2 (1.0, 1.4) | 1.0 (0.9, 1.1) | 0.05 |
NOS1 | rs1353939 | 1.0 (0.9, 1.2) | 0.9 (0.8, 1.1) | 0.2 | 1.1 (0.9, 1.2) | 1.0 (0.8, 1.1) | 0.3 | 1.1 (1.0, 1.3) | 1.0 (0.8, 1.2) | 0.04 |
NOS1 | rs2291908 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.4 | 1.1 (0.9, 1.3) | 1.0 (0.9, 1.1) | 0.3 | 1.1 (1.0, 1.3) | 1.0 (0.9, 1.1) | 0.05 |
NOS1 | rs4767535 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.9 | 1.0 (0.8, 1.3) | 1.0 (0.9, 1.1) | 0.9 | 1.2 (1.0, 1.5) | 1.0 (0.9, 1.1) | 0.05 |
NOS1 | rs6490121 | 1.0 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.9 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.6 | 0.6 (0.2, 1.5) | 1.1 (1.0, 1.1) | 0.05 |
NOS1 | rs7298903 | 1.0 (0.9, 1.1) | 0.7 (0.5, 1.1) | 0.05 | 1.0 (0.9, 1.1) | 0.8 (0.6, 1.2) | 0.3 | 1.1 (1.0, 1.1) | 1.1 (0.9, 1.4) | 0.5 |
NOS2A | rs944725 | 1.1 (0.9, 1.3) | 1.0 (0.9, 1.1) | 0.2 | 1.1 (0.9, 1.4) | 1.0 (0.9, 1.1) | 0.2 | 1.3 (1.0, 1.6) | 1.0 (0.9, 1.1) | 0.03 |
NOS2A | rs4795067 | 1.1 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.3 | 1.1 (1.0, 1.3) | 0.9 (0.8, 1.1) | 0.05 | 1.2 (1.0, 1.6) | 1.0 (0.9, 1.1) | 0.02 |
NOS2A | rs2297516 | 0.9 (0.7, 1.1) | 1.1 (0.9, 1.2) | 0.05 | 0.9 (0.8, 1.1) | 1.1 (0.9, 1.3) | 0.2 | 1.0 (0.9, 1.1) | 1.1 (0.9, 1.2) | 0.7 |
NOS2A | rs2779252 | 1.0 (0.9, 1.1) | 0.9 (0.8, 1.1) | 0.5 | 1.0 (0.9, 1.2) | 1.0 (0.8, 1.1) | 0.7 | 1.1 (1.0, 1.3) | 0.2 (0.001, 36.1) | 0.03 |
NOS2A | rs8072199 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.9 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.9 | 0.1 (0.005, 3.7) | 1.1 (1.0, 1.1) | 0.03 |
NOS3 | rs1799983 | 0.9 (0.7, 1.1) | 1.0 (0.9, 1.1) | 0.1 | 0.9 (0.7, 1.1) | 1.1 (1.0, 1.2) | 0.04 | 1.1 (1.0, 1.2) | 1.1 (1.0, 1.2) | 0.4 |
NOS3 | rs4496877 | 1.0 (0.8, 1.3) | 1.0 (0.9, 1.1) | 0.6 | 1.2 (0.9, 1.5) | 1.0 (0.9, 1.1) | 0.1 | 1.3 (1.0, 1.8) | 1.0 (1.0, 1.1) | 0.02 |
NOS3 | rs12703107 | 0.8 (0.7, 1.0) | 1.0 (0.9, 1.1) | 0.04 | 0.7 (0.6, 1.0) | 1.0 (0.9, 1.1) | 0.007 | 1.1 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.6 |
RAC1 | rs836554 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 0.7 | 1.1 (0.9, 1.2) | 1.0 (0.8, 1.1) | 0.3 | 1.2 (1.0, 1.4) | 0.9 (0.7, 1.2) | 0.01 |
RAC1 | rs6463554 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 0.8 | 1.0 (0.9, 1.2) | 1.0 (0.8, 1.1) | 0.5 | 1.2 (1.0, 1.3) | 0.9 (0.6, 1.3) | 0.01 |
RAC1 | rs3729790 | 1.0 (0.9, 1.1) | 0.9 (0.7, 1.1) | 0.2 | 1.0 (0.9, 1.1) | 0.8 (0.6, 1.1) | 0.2 | 1.0 (0.9, 1.1) | 1.2 (1.0, 1.5) | 0.04 |
RAC2 | rs6572 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.7 | 1.1 (0.9, 1.3) | 1.0 (0.9, 1.1) | 0.3 | 1.2 (1.0, 1.3) | 1.0 (0.9, 1.1) | 0.04 |
RAC2 | rs1476002 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 0.6 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.6 | 1.2 (1.0, 1.3) | 0.9 (0.7, 1.3) | 0.02 |
RAC2 | rs2239774 | 1.1 (1.0, 1.2) | 0.6 (0.4, 0.9) | 0.0006 | 1.1 (1.0, 1.3) | 0.3 (0.08, 1.2) | 0.0002§ | 1.1 (1.0, 1.3) | 1.0 (0.9, 1.1) | 0.1 |
RAC2 | rs2239775 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 0.8 | 1.0 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.7 | 1.2 (1.0, 1.4) | 0.8 (0.4, 1.5) | 0.005 |
RAC2 | rs4820274 | 1.0 (0.9, 1.1) | 0.8 (0.6, 1.1) | 0.2 | 1.0 (0.9, 1.1) | 0.2 (0.02, 1.1) | 0.002 | 1.1 (1.0, 1.1) | 1.3 (0.9, 2.0) | 0.3 |
RAC2 | rs4821609 | 1.0 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.8 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.9 | 1.2 (1.0, 1.3) | 0.9 (0.7, 1.3) | 0.02 |
RAC2 | rs9607432 | 1.0 (0.9, 1.1) | 0.6 (0.4, 1.0) | 0.04 | 1.0 (0.9, 1.1) | 0.2 (0.03, 1.3) | 0.005 | 1.1 (1.0, 1.1) | 1.3 (0.9, 2.0 | 0.3 |
SOD1 | rs202445 | 0.9 (0.8, 1.1) | 1.1 (0.9, 1.3) | 0.1 | 0.9 (0.8, 1.1) | 1.2 (1.0, 1.4) | 0.03 | 1.0 (0.9, 1.1) | 1.2 (1.0, 1.5) | 0.2 |
SOD2 | rs4880 | 0.9 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.1 | 0.8 (0.6, 1.1) | 1.1 (1.0, 1.2) | 0.02 | 1.1 (1.0, 1.2) | 1.1 (0.9, 1.3) | 0.7 |
SOD2 | rs5746136 | 1.0 (0.9, 1.1) | 0.9 (0.8, 1.1) | 0.4 | 1.0 (0.9, 1.1) | 0.9 (0.8, 1.1) | 0.3 | 0.9 (0.5, 1.4) | 1.2 (1.0, 1.3) | 0.02 |
SOD2 | rs5746151 | 1.0 (0.9, 1.1) | 1.3 (0.7, 2.3) | 0.4 | 1.0 (0.9, 1.1) | 0.9 (0.4, 1.9) | 0.8 | 1.0 (0.9, 1.1) | 1.7 (0.8, 3.5) | 0.02 |
SOD3 | rs699473‡ | 0.9 (0.8, 1.1) | 1.0 (0.9, 1.1) | 0.1 | 1.0 (0.9, 1.1) | 1.1 (1.0, 1.2) | 0.1 | 0.8 (0.4, 1.3) | 1.2 (1.1, 1.3) | 0.003 |
XDH | rs7574920 | 1.0 (0.8, 1.2) | 1.0 (0.9, 1.1) | 0.9 | 1.0 (0.8, 1.3) | 1.0 (0.9, 1.1) | 0.8 | 1.3 (1.0, 1.6) | 0.8 (0.6, 1.2) | 0.001§ |
XDH | rs1429376 | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.1) | 0.4 | 1.1 (1.0, 1.3) | 0.9 (0.8, 1.1) | 0.06 | 1.2 (1.0, 1.4) | 0.9 (0.6, 1.3) | 0.005 |
XDH | rs17038412 | 1.0 (0.9, 1.1) | 1.0 (0.8, 1.2) | 0.7 | 1.0 (0.9, 1.1) | 1.2 (0.9, 1.5) | 0.1 | 1.1 (1.0, 1.1) | 0.3 (0.05, 1.8) | 0.03 |
XDH | rs6718606 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.1) | 0.5 | 1.0 (0.9, 1.2) | 1.0 (0.8, 1.1) | 0.4 | 1.1 (1.0, 1.3) | 1.0 (0.8, 1.2) | 0.04 |
See Table 2 for genotype frequencies and associations with brain tumor types
Cases with glioblastoma are a subset of the cases with glioma
GPX1 rs1050450 is highly correlated with rs1800668 (r2 = 0.9); SOD3 rs699473 is highly correlated with rs2284659 (r2 = 0.9)
p ≤ 0.05 after adjustment for multiple comparisons