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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Aug 15;50(1):249–255. doi: 10.1167/iovs.08-1891

Figure 3.

Figure 3

High-dose therapeutic and preventive treatment with voclosporin preserved the retinal architecture in IRBP-immunized rats. At d0, rats were immunized with IRBP to induce uveitis. Subcutaneous preventive (d0 – d13) or therapeutic (d7 – d13) injections of CsA or voclosporin were administered. Animals were humanely euthanatized on d14, and ocular tissues were histologically processed. Retinal tissue sections (×100) stained with hematoxylin and eosin. (A) Vehicle, miglyol 812 oil. (B) CsA (high-dose preventive, 40 mg/kg). (C) Voclosporin (low-dose therapeutic, 2.5 mg/kg). (D) Voclosporin (medium-dose therapeutic, 10 mg/kg). (E) Voclosporin (high-dose therapeutic, 40 mg/kg). (F) Voclosporin (high-dose preventive, 40 mg/kg). White arrows: retinal folds and small granuloma formation. Black arrows: inflammatory cellular infiltrates surrounding retinal vessels and in the vitreous.