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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Aug 15;50(1):249–255. doi: 10.1167/iovs.08-1891

Figure 4.

Figure 4

Lymphocytes from animals treated with voclosporin underwent decreased antigen-specific proliferation. Rats were immunized with IRBP (d0) to induce uveitis and were injected subcutaneously (d0 – d13 [preventive] or d7 – d13 [therapeutic]) with voclosporin (low dose, 2.5 mg/kg; medium dose, 10 mg/kg; high dose, 40 mg/kg). At the termination of the experiment on d14 after immunization, triplicate cultures of lymphocytes (2 × 105 cells/well) were stimulated with IRBP (5 μg/mL) in 96-well plates. To monitor the effects on cell proliferation, cultures were incubated for 7 days and were pulsed with 1 μCi [3H] thymidine for the last 16 hours. Data are represented as mean CPM ± SEM. Data were analyzed with the use of ANOVA followed by Bonferroni multiple comparison test to identify differences among groups (*P < 0.05; **P < 0.01).