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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Aug 15;50(1):249–255. doi: 10.1167/iovs.08-1891

Figure 5.

Figure 5

Voclosporin suppresses human lymphocyte proliferation. Purified human T cells (200,000 cells/well) in a 96-well plate were stimulated with anti-CD28 and anti-CD3 antibodies for 30 minutes, followed by cross-linking with mouse anti-human IgG. Cells were pulsed with 3H-thymidine for 16 hours, and proliferation in the presence of 0.1 to 100 nM voclosporin or 10 to 100 nM CsA was analyzed on d5. Data are plotted as stimulation index (SI) with an indication for minimum, median, and maximum values. The denominator used for calculation of SI (background CPM) is indicated below each graph. Kruskal-Wallis ANOVA was performed, followed by Dunn multiple comparison test to determine differences among all groups (*P < 0.05; **P < 0.01).