Table 2 Patient series with erythropoietic protoporphyria (EPP) worldwide with details of liver disease.

First author	Year	Country	No of patients	% with hepatobiliary disease	Comment
Schmidt35	1974	Denmark	29	3%	Biochemistry not performed in all cases; 1 patient with porphyrin deposits in liver biopsy
DeLeo36	1976	USA	32	4%	No severe liver disease
Went,16 Baart de la Faille37	1984	Netherlands	200	6%	9 with gallstones, 3 young patients with cirrhosis
Murphy38	1985	UK	382	>1%	3 patients with acute hepatic failure
Gross,41 Lehmann,40 Frank39	1998	Germany	140	∼25%	Severe liver disease in 10% of patients
Minder,31 Rüfenacht30	2002	Switzerland and France	55	16%	9 patients with liver disease
Chen33	2002	USA	34	41%	Highly selected series. Included 10 patients who underwent liver transplant
Wiman20	2003	Sweden	9	10%	1 patient with severe liver disease requiring liver transplantation