Table 3 Published clinical reports of liver transplants for erythropoietic protoporphyria (EPP)‐related liver failure.

First author	Year	Sex	Age	Complications	Outcome
Wells11	1980	M	19	Death at 4 weeks after transplantation	Death attributed to disseminated candidiasis
Polson91	1988	M	13	Initially none	First liver rejected. Death from complications after second liver transplant
Samuel9	1988	F	24	Transplanted liver functioned poorly initially	Alive at 40 months. Good outcome
Bloomer92	1989	F	38	None	Patient well 13 months after transplant but with mild hepatic fibrosis in transplant
		M	51	Severe skin necrosis and photo‐injury to intestines	Death secondary to multiple intestinal perforations
Wagner93	1989	M	49	Sepsis	Died 2 months after transplant
Herbert82	1991	F	42	Skin burns and neuropathy	Slow recovery. Alive at 36 months
Shehade95	1991	F	40	Skin burns and severe neuropathy	Well 3 years after transplant. Mild neuropathy persisted
Steinmüller94	1992	M	51	Successful transplant	Well 1 year after transplant
Mion64	1992	M	38	Postoperative seizures	Medium term survival (at least)
Ozawa96	1992	M	15	Surgery successful	No follow‐up published
Schleiffenbaum97	1992	F	40	Surgery successful	Patient well 5 months after transplant
Key75 (Bloomer32)	1992	M	51	Skin burns, small GI bleed, severe haemolytic anaemia	Sepsis and death 73 days after surgery
	1992	M	13	Severe motor neuropathy, severe haemolytic anaemia	Good recovery following surgery
Sarkany13	1993	F	17	None	Well 14 months after surgery
Rank98	1993	F	36	Postoperative bleeding	Multiorgan failure; death 5 weeks after transplantation
		M	51	Severe postoperative neuropathy and skin burns	Death within weeks of transplant due to complications including sepsis
		M	13	Massive haemolysis during surgery. Severe neuropathy	Patient at home and able to care for himself 1 year after transplant
		M	27	Severe postoperative neuropathy	Gradual recovery of muscle strength
		F	18	Minor skin burns	Good recovery after transplant
Meerman58,104	1994	F	34	Repeat laparotomy for postoperative bleed	Liver fibrosis present 2 years after surgery; remains well 7 years after transplant
		F	39	None	Portal fibrosis in transplant at 6 and 12 months after transplant. Liver fibrosis progressing at 7 years after transplant
de Torres89	1996	F	41	None	Good outcome initially, but protoporphyrin damage to transplanted liver
Lock99	1996	F	58	Severe polyneuropathy	Neuropathy persists 1 year after transplant, general condition markedly improved
Harper,83 Thunell100	1998	M	50	Phototoxic abdominal burns, intestinal bleeding after surgery	Death from multiorgan failure 1 month after transplant
Gross41	1998	M	39	None	Excellent health 5 years after surgery
		M	51	Intrahepatic cholestasis
		F	59	None	Marked improvement 1 year after surgery
		F	59	Accumulation of protoporphyrin in transplant	Post‐transplant health good
		F	17	None	Good
		F	58	None	Good
		M	38	None	Good
Rüfenacht30	1998	F	49	Cholestasis corrected, liver function normalised	Follow‐up 4 years after transplant
		F	35	Cholestasis corrected, liver function normalised	Follow‐up 2 years after transplant
Nguyen101	1999	M	54	Polyneuropathy	Most of neuropathy had recovered 12 months after surgery
Reicheld,65 Do102	1999 2002	M	55	Mild rejection episode at 3 months	Use of plasmapheresis and IV haem‐albumin to protect transplanted liver
Jimenez‐Saenz103	1999	M	59	None	Good health 30 months after transplant
Leone105	2000	M	35	None	Excellent health 4 years after transplant
	2000	M	50	Poor health after transplant	Died 1 month after transplant
Dellon90	2002	M	54	Neuropathy	Transplanted liver affected by protoporphyrin.
Schoenfeld34	2003	M	29	None	3 year postoperative follow‐up