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Percent AUC Changes in Humans with Probe Drugs for Various CYP Enzymes
| CYP | Drug Probes | Percent AUC Decrease |
|---|---|---|
| CYP1A | Theophylline | 15–66% |
| CYP2B6 | Efavirenz | 20–30% |
| CYP2C8 | Rosiglitazone/Repaglinide | 32–80% |
| CYP2C9 | Warfarin/Tolbutamide | 16–63% |
| CYP2C19 | Omeprazole | 25–49% |
| CYP3A4 | Midazolam | 20–98% |
Data taken from the University of Washington Metabolism and Transport Drug Interaction database. http://www.druginteractioninfo.org/
