Table I.
Composition of different mucoadhesive microsphere formulation
| Formulation code | Drug concentration (% w/w) | Polymer concentration (% w/v) | Cross linker (ml) | Maltodextrina (%) | Aerosilb (%) | Propylene glycolc (%) |
|---|---|---|---|---|---|---|
| M-CH | 0.3 | 2.0 | 1 | – | – | – |
| M-TCH | 0.3 | 2.0 | 1 | – | – | |
| M-CA | 0.3 | 2.0 | – | 80 | 10 | 30 |
| M-ME | 0.3 | 2.0 | – | 80 | 10 | 30 |
M-CH Chitosan microsphere, M-TCH thiolated chitosan microsphere; M-CA Carbopol 71G microsphere, M-ME Methocel K15M microsphere
aPercentage by weight of the total amount of drug and polymer
bPercentage by weight of formulation.
cPercentage by weight of amount of polymer