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Time course of inhibition of plasma DPP4 activity after administration of placebo (open circles) or single oral doses of sitagliptin—1.5 (solid circles), 12.5 (open squares), 50 (solid squares), and 200 (open triangles) mg (A) and 5 (solid circles), 25 (fed [solid squares] and fasted [open squares]), and 100 (open triangles) mg (B) to healthy, young male subjects. [Reprinted with permission from Macmillan Publishers Ltd: Clinical Pharmacology and Therapeutics (78(6), copyright Dec 2005]
