Table 1.
Pharmacokinetic Parameters Obtained after Ivermectin Oral Administration
| Reference | Dose | Absorption | Elimination | |||
|---|---|---|---|---|---|---|
| C max (ng·ml−1) | t max (h) | t 1/2(abs) (h) | t 1/2 (h) | Cl (1 kg−1·day−1) | ||
| Healthy subjects | ||||||
| 9a | 12 mg (tablet) | – | – | – | 12 | – |
| 8a | 6 mg (tablet) | 23.1 | 4.3 | 0.5 | 12.6 | 4.28 |
| 8a | 12 mg (tablet) | 30.4 | 10.3 | 2.5 | 13.4 | 4.03 |
| 9a | 6 mg (tablet) | 20.2 | 4.7 | 1.4 | 11.1 | 7.57 |
| 9a | 12 mg (tablet) | 23.5 | 5.3 | 1.4 | 21.1 | 6.53 |
| 9a | 18 mg (tablet) | 31.2 | 5.1 | 1.7 | 16.7 | 10.6 |
| 11 | 12 mg (solution) | 81 | 3.6 | – | – | – |
| 11 | 12 mg (tablet) | 50 | 3.4 | – | – | – |
| 11 | 12 mg (capsule) | 46 | 3.6 | – | – | – |
| 12 | 150 μg/kg | 54.4 | 4.9 | – | 36.6 | – |
| 13 | 150 μg/kg | 37.9 | – | – | – | – |
| 14 | 150 μg/kg | 33.8 | – | – | 4.70 (♂) 8.40 (♀) | |
| Onchocerciasis patients | ||||||
| 12 | 150 μg/kg | 52.2 | 5.2 | – | 35.0 | – |
| 15 | 150 μg/kg | 39 | 5.6 | – | 16 | – |
| 16 | 6 mg (tablet) | 38.2 | 4.7 | – | 54.5 | 3.1 |
| 17 | 150 μg/kg | 19.9 | – | |||
– Unknown data; C max maximum plasma concentration; t max time to reach C max; t 1/2abs absorption half-life; t 1/2 elimination half-life; Cl total body clearance
aOne-compartment model