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Dosing Regimens and PK Analyses Employed in this Work
| Study # | Compound Administered-(mmol/kg) | PK Determined | ||||
|---|---|---|---|---|---|---|
| BD | GHB | ETOH | BD | GHB | ETOH | |
| 1 | 6.34 | Yes | ||||
| 2 | 12.7 | Yes | ||||
| 3 | 1.79 | Yes | ||||
| 4 | 6.34 | Yes | ||||
| 5 | 1.58 | Yes | Yes | |||
| 6 | 6.34 | Yes | Yes | |||
| 7 | 1.58 | 6.34 | Yes | Yes | ||
| 8 | 1.58 | 12.7 | Yes | Yes | Yes | |
| 9 | 6.34 | 6.34 | Yes | Yes | Yes | |
| 10 | 1.58 | 6.34 | Yes | |||
| 11 | 6.34 | 6.34 | Yes | Yes | ||
| 12 | 1.58POa | Yes | Yes | |||
| 13 | 6.34POa | Yes | Yes | |||
Except otherwise stated, doses were administered intravenously as a 5-min infusion
aAdministered by oral intubation
