. 2008 Mar 14;10(1):157–165. doi: 10.1208/s12248-008-9017-8

Table I.

Pharmacokinetic Parameters (Mean ± SD) of Lee 562, Lee 878, Lee 952 and Lee 1106

Route	Compound	t (h)	AUCinf (μg h/L)	Volume of Distribution L/kg	Clearance (L h⁻¹ kg⁻¹)	% Dose Excreted		Bioavailability (%)
Route	Compound	t (h)	AUCinf (μg h/L)	Volume of Distribution L/kg	Clearance (L h⁻¹ kg⁻¹)	Urine	Feces	Bioavailability (%)
IV	Lee 562	1.30 ± 0.89	956 ± 442	28.9 ± 29.4	12.9 ± 7.6	0.001 ± 0.0003	0.001 ± 0.001
	Lee 878	2.63 ± 0.35	19,091 ± 1,724	2.00 ± 0.36	0.527 ± 0.05	ND	ND
	Lee 952	7.34 ± 2.27	1,846 ± 82.2	58.0 ± 20.1	5.42 ± 0.24	ND	ND
	Lee 1106	10.3 ± 1.41	22,423 ± 4,096	6.72 ± 1.10	0.456 ± 0.07	0.035 ± 0.01	0.14 ± 0.06
Oral	Lee 562	3.69 ± 0.86	1,519 ± 458	386 ± 187	71.6 ± 23.2	0.009 ± 0.02	0.023 ± 0.02	15.9 ± 4.8
	Lee 878	ND	52,324 ± 14,834^b	ND	2.07 ± 0.71^c	ND	ND	27.4 ± 7.8^c
	Lee 952	3.39 ± 1.16^a	2,936 ± 1,119	192 ± 127	37.7 ± 12.5	ND	ND	15.9 ± 6.1
	Lee 1106	9.24 ± 1.71	10,230 ± 9,101	231 ± 174	16.0 ± 10.3	0.025 ± 0.02	11.8 ± 7.09	4.6 ± 4.1

ND Not determined

^aNot reliable determined due to limited log-linear phase

^bAUC_0–48 h

^cAUC_0–48 h was used for calculation of clearance and oral bioavailability