Table II.
Aqueous Solubility and Plasma Protein Binding of Lee 562, Lee 878, Lee 952 and Lee 1106
| Compound | Molecular Weight | MIC90 (μg/mL) | clogP | Solubility (mg/L) | % Protein Binding | |
|---|---|---|---|---|---|---|
| pH 6.0 | pH 7.4 | |||||
| Lee 562 | 421.4 | 0.0062 | 2.41 | 18.5 | 4.43 | 96.43 |
| Lee 878 | 432.5 | 0.00005 | 4.29 | 3.34 | 0.24 | 99.92 |
| Lee 952 | 389.4 | 0.09 | 1.91 | 1975 | 759 | 44.53 |
| Lee 1106 | 517.5 | 0.025 | 6.41 | BLQ | 2.67 | 99.99 |
MIC 90 Minimum inhibitory concentration to inhibit the growth of 90% of organisms determined against M. tuberculosis H37Rv using microbroth dilution in Middlebrook 7H9
BLQ Below the limit of quantification