Table III.
Inhibitors Used for Microsomal Reaction Phenotyping Incubations
| CYP | Inhibitor | Stock Solution | Final concentration (μM) |
|---|---|---|---|
| CYP1A1/2 | Furafylline (38,39,40) | 5 mM in acetonitrile | 20 |
| CYP2C9 | Sulfaphenazole (40,41) | 5 mM in acetonitrile | 20 |
| CYP2C19 | 3-Benzylnirvanol (42,43) | 1.25 mM in acetonitrile | 5 |
| CYP2D6 | Quinidine(40,44,45) | 1.25 mM in acetonitrile | 5 |
| CYP3A4 | Ketoconazole(40) | 250 μM acetonitrile | 1 |
| Troleandomycin (44,46,47) | 12.5 mM in acetonitrile | 100 |
Final concentration of organic solvent in the incubation mixture is 0.4% (v/v) except for troleandomycin (0.8%).