Figure 5.

Hepatic expression of CXC chemokines is associated with MPO-mediated oxidative damage and neutrophil sequestration in NAFLD. A: Hepatic expression of IL-8 and GRO-α is higher in patients that show accumulation of HOCl-modified proteins and nitrotyrosine as compared with patients without accumulation of MPO-mediated oxidative products (*P = 0.04 and **P = 0.05, respectively). B: Significant correlation between hepatic IL-8 mRNA expression and hepatic neutrophil infiltration (r_s = 0.44, P < 0.01) and GRO-α mRNA expression and hepatic neutrophil infiltration (r_s = 0.42, P < 0.01). C: Gene expression of both IL-8 (P = 0.76) and GRO-α (P = 0.64) is elevated but not significantly increased in the liver of subjects with NASH in comparison with severely obese subjects with only steatosis.