Figure 5.

Cytokine expression and neutrophil infiltration is increased in Pkd2 heterozygous mice compared with wild-type following IRI. A: Significantly greater increases in IL-1β and KC were detectable in the postischemic LK of heterozygous mice compared with their wild-type littermates at 2 days. Levels of other detectable cytokines, including IL-12p40, were not different between genotypes and unchanged by ischemia. B: There were a greater number of neutrophils (myeloperoxidase-positive cells) at 2 days in both interstitium and glomeruli of postischemic LK of heterozygous mice compared with their wild-type littermates. ^∗P < 0.05 (n = 5–7).