Figure 2.

Morphological analysis of the liver of the core gene transgenic mice. Representative cases are shown either treated with tacrolimus (FK506) or vehicle (H&E staining). A: There is a prominent improvement of steatosis in the 3-month tacrolimus-treated core gene transgenic mice compared with the vehicle-treated mice. B: A prominent improvement in steatosis was also obtained by the administration of one-fifth dose of tacrolimus for 1 month beginning at 3 months of age. For histological analysis, two independent researchers evaluated 40 microscopic fields each, and a representative picture is shown for each category. Original magnification, ×125. Tg, transgenic mice; nTg, nontransgenic control mice.