Table 2.

Overview of the Phenotypes Exhibited in Single and Double Knockout Mice for Major Skeletal Muscle Laminin Receptors

	mdx	α7−/−	utr−/−	mdx/utr−/−	mdx/α7−/−	α7/utr−/−
Lifespan	Almost normal	>1 year	Normal	20 weeks	4 weeks	>1 year
Embryonic lethality	None	Partial	None	None	Partial	Partial
Weight at 21 days	Normal	Normal	Normal	Reduced	Reduced	Normal
Skeletal muscle pathology	Moderate	Minor	None	Severe	Severe	Minor
Joint contractures	None	None	None	Severe	Severe	None
Kyphosis	None	None	None	Severe	Severe	None
MTJ	Reduced sarcolemmal folds	Reduced sarcolemmal folds	No	Reduced sarcolemmal folds	Reduced sarcolemmal folds	Reduced myofiber adhesion
NMJ defects	None	None	Mild	Severe	Not reported	None
References	4, 11, 43, 44	26, 29	12, 15	11, 13, 14	28, 31	This paper