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Absence of MKP-1 dramatically accentuates bone resorption in response to local injection of LPS. Eight-week-old mkp-1−/− and mkp-1+/+ male and female mice were injected with 25 μg of LPS in a 2-μl volume in the periosteum of the right calvaria. Note the dramatic response of MKP1-deficient mice to LPS. Numbers represent mean % (±SD) resorbed bone surface. n = 4.
