Table 3.
Rate ratio for epilepsy in offspring of women with and without a history of spontaneous abortion
| History of spontaneous abortion* |
No history of spontaneous abortion |
||||
|---|---|---|---|---|---|
| Proband characteristics | No. of offspring (No. affected) | Cumulative incidence to age 25 | No. of offspring (No. affected) | Cumulative incidence to age 25 | Rate ratio (95% CI) |
| Family history of epilepsy† | |||||
| Yes | 21 (4) | 21.9 | 33 (1) | 7.6 | 7.5 (0.8–67.5) |
| No | 225 (23) | 12.1 | 512 (18) | 4.6 | 2.9 (1.6–5.3)‡ |
| Age at onset of epilepsy | |||||
| 0–9 y | 44 (16) | 16.7 | 89 (6) | 11.1 | 2.9 (1.6–5.3)‡ |
| 10–19 y | 93 (12) | 16.3 | 198 (4) | 2.7 | 6.4 (2.1–20.0)‡ |
| 20–35 y | 65 (8) | 14.7 | 274 (9) | 7.7 | 2.3 (0.9–5.9) |
| >35 y | 43 (1) | 2.4 | 81 (0) | — | — |
| Education | |||||
| <High school | 136 (18) | 15.1 | 234 (6) | 3.8 | 5.4 (2.2–13.7)‡ |
| ≥High school | 110 (9) | 10.0 | 311 (13) | 5.3 | 1.8 (0.8–4.3) |
| Ethnicity | |||||
| Nonwhite | 32 (3) | 12.4 | 104 (10) | 10.8 | 0.9 (0.2–3.3) |
| White | 210 (24) | 13.4 | 438 (9) | 3.2 | 5.6 (2.6–12.2)‡ |
| Gestational seizures | |||||
| Yes | 82 (15) | 21.7 | 169 (4) | 3.5 | 7.6 (2.5–23.0)‡ |
| No | 149 (12) | 9.7 | 343 (9) | 3.6 | 3.1 (1.3–7.4)‡ |
*
History of spontaneous abortion considered positive if at least one pregnancy was terminated in spontaneous abortion.
†
Family history of epilepsy considered positive if at least one parent or sibling was affected.
‡
p < 0.05.