Table 1.
Formulation | Concn. Unfiltered (mg/mL) | Concn. In Aqueous Filtrate (mg/mL) | Difference in Concn. pre and post filtration (mg/mL)** |
---|---|---|---|
A5 | 1.02 ± 0.04 | 1.02 ± 0.04 | 0.01 ± 0.01 |
A5NaCL | 1.00 ± 0.01 | 0.94 ± 0.03 | 0.06 ± 0.02 |
Phosphate | 0.99 ± 0.02 | 0.95 ± 0.05 | 0.04 ± 0.02 |
PBS | 1.02 ± 0.01 | 0.98 ± 0.03 | 0.04 ± 0.02 |
A5 polysorbate20 | 0.99 ± 0.02 | 0.98 ± 0.01 | 0.01± 0.01 |
A5 sucrose | 1.04 ± 0.03 | 0.99 ± 0.04 | 0.03 ± 0.01 |
The mean ± SD was calculated from triplicate set of samples each replicate prepared using different syringes and filter.
The mean ± SD was calculated from differences in concentration measured for each replicate for a given solution.