Table 1. Classes of primate segmental duplication.
Copy-Number Corrected Duplicated Basepairs | |||||||
---|---|---|---|---|---|---|---|
Category | SD | SD >20 kbp | %Validation | HSA | PTR | PPY | MMU |
HSA | 51,458,805 | 15,236,422 | 89-92% | 17,847,869 | |||
PTR | 11,239,390 | 4,789,874 | 99% | 16,583,946 | |||
PPY | 30,553,228 | 6,417,679 | 98% | 23,327,737 | |||
MMU | 24,962,092 | 5,360,646 | 45% | 45,810,964 | |||
MMU* | 35,493,466 | 7,715,410 | 85% | 18,266,656 | |||
HSA / PTR | 32,392,480 | 21,061,194 | NA | 21,524,417 | 26,304,286 | ||
HSA / PTR / PPY | 25,450,827 | 13,402,545 | NA | 11,259,061 | 14,012,351 | 11,541,148 | |
HSA / PTR / PPY / MMU | 14,094,156 | 7,156,616 | NA | 8,092,997 | 12,820,607 | 6,176,876 | 12,542,691 |
Total | 190,150,978 | 73,424,976 | 58,724,344 | 69,721,190 | 41,045,761 | 30,809,347 |
Duplications were divided into eight categories based on the WSSD analysis of each primate genome (subsequent analysis were restricted to SDs >20 kbp in length). Lineage specific and shared duplication content are indicated. % validation indicates the fraction of species-specific duplications confirmed by cross-species array comparative genomic hybridization. Because the human genome was used, we corrected for copy number and examined sequence contigs not aligned to the human genome (see Methods). SDs assigned to the Y chromosome were not considered.
Macaque SDs detected in the macaque reference genome using WSSD and WGAC (<94% ID) approaches.