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Effect of siRNA PARs on IL-4 (A) and IL-6 (B) release from P815 cells. Cells were transfected with 10 nM of siRNA PAR-1.2, siRNA PAR-2.3 or siRNA PAR-4.3 for 48 h before protease or agonist of PAR being added for 16 h at 37°C. Values shown are mean ± SEM for four to five independent experiments. * P < 0.05 compared with the response of untransfected cells to the corresponding stimulus.
