Table 3.

Summary statistics on haplotype-based association

Gene	SNP identifiers and omnibus association	Haplotype	F patients	F controls	χ2	p
OPTN	rs10796021|rs3829923|rs7921853|rs765884	TTGT	0.257	0.327	5.905	0.015
	pomnibus = 0.014	CCGT	0.125	0.142	0.590	0.443
	χ2 omnibus = 23.67	TCTT	0.129	0.119	0.243	0.622
		CCTC	0.187	0.093	18.170	2.021 × 10-5
		TCTC	0.062	0.073	0.484	0.487
		CCTT	0.072	0.070	0.019	0.890
		CTGT	0.048	0.056	0.293	0.588
		TTTT	0.036	0.040	0.083	0.773
		TCGT	0.023	0.031	0.728	0.394
		CCGC	0.029	0.029	0.003	0.959
		CTTC	0.014	0.013	0.023	0.880
		TTGC	0.018	0.009	1.611	0.204
MFN2	rs873458|rs2295281|rs11588779	ATC	0.410	0.420	0.1083	0.742
	pomnibus = 0.018	GCC	0.359	0.286	6.541	0.011
	χ2 omnibus = 11.97	ATT	0.091	0.147	8.334	3.891 × 10-3
		GCT	0.131	0.135	0.039	0.843
		GTC	0.009	0.011	0.099	0.753
PARL	rs1000002|rs1402003	TA	0.461	0.540	4.049	0.044
	pomnibus = 7.619 × 10-4	CG	0.464	0.344	9.758	1.786 × 10-3
	χ2 omnibus = 16.84	CA	0.075	0.093	0.7123	0.399
		TG	0	0.023	8.480	3.590 × 10-3

F, frequency