Table 1.

Binding of [³H]-PK11195 following cortical contusion injury in COX-1 +/+ and COX-1 -/- mice.

	COX-1 +/+		COX-1 -/-
Brain Region	Uninjured	Injured	Uninjured	Injured
CA1	5.35 ± 0.97	5.55 ± 1.07	3.71 ± 0.50†	4.46 ± 0.38*†
CTX	3.01 ± 0.23	3.63 ± 0.70	2.95 ± 0.22	3.36 ± 0.35
DLG	2.65 ± 0.18	4.09 ± 0.79*	2.48 ± 0.14	4.15 ± 1.10*
LPM	2.83 ± 0.15	3.72 ± 0.41*	2.66 ± 0.26	3.87 ± 0.85*
DG	5.00 ± 1.58	7.15 ± 2.52*	4.66 ± 0.54	6.59 ± 0.78*
VPL/VPM	2.16 ± 0.14	2.56 ± 0.27*	2.07 ± 0.18	2.54 ± 0.40*

Binding studies conducted on mice euthanatized 9 days after injury. Data is expressed as mean ± SD of μCi/mg of wet tissue. * represents significant changes compared to the uninjured hemispere; † represents significant changes compared to the corresponding hemisphere of the COX-1 +/+ animals. CA1, CA1 region of the hippocampus; CTX, cortex; DLG, dorsal lateral geniculate nucleus; LPM, lateral posterior nucleus; DG, dentate gyrus; VPL/VPM, ventral posteriolateral/medial thalamic nucleus.