Table 1.
System | Protein Residue | |||||
---|---|---|---|---|---|---|
Tyr505 | Phe506 | IIe492 | Asn513 | Arg514 | Arg517 | |
A:C | inactive | active | active | active | active | active |
A:G | inactive | active | active | new | inactive | active |
A(syn):G | inactive | active | active | new | active | active |
T:G | mainly nactive |
mainly active, but briefly inactive |
inactive & new |
new | active | mainly active with small conformational changes |
A(syn):A | inactive | inactive | inactive & new |
active | active | mainly active with small conformational changes |
A:A | inactive, ctive, & new |
active and sideways variant |
active | active | intermediate | active |
Table Definitions: inactive, refers to side-chain orientation in binary pol λ /DNA complex (PDB entry 1XSL)
active, refers to side-chain orientation in ternary pol λ/DNA/dTTP complex (PDB entry 1XSN)
new, refers to side-chain orientation not captured crystallographically
intermediate, refers to side-chain orientation lying between the active and inactive positions