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Effect of ROS donors and pretreatment with SOD and catalase on voltage-gated calcium channel (VGCC) currents from neonatal and adult rat ICG neurons (22 °C).
| Preparation | % inhibition of VGCC current amplitude (n) |
|||
|---|---|---|---|---|
| 1 mM H2O2 | 1 mM t-BHP | 100 U/ml SOD | 100 U/ml catalase | |
| Neonate ICG | 13.9 ± 2.6 (8) ⁎⁎ | 17.9 ± 1.9 (5) ⁎⁎ | 12.5 ± 4.8 (4) | 13.7 ± 3.7 (4) |
| Adult ICG | 9.8 ± 1.4 (6) ⁎ | 16.5 ± 1.6 (3) ⁎⁎ | 0 (3) | ND |
ND, not determined; n, number of cells; ⁎P < 0.05, ⁎⁎P < 0.01.
