Table 2.

GO term enrichment for genes significantly up-regulated or down-regulated in Δssb1Δssb2 based on the Affymetrix yeast 2.0 array analysis (Supplemental Table S3)

Lists of genes that were significantly up-regulated or down-regulated (at least 1.5-fold in Δssb1Δssb2 compared with wild type, false discovery rate ≤ 5%) were selected for the analysis. Shown are the results of Fisher's exact test for overrepresentation of the up-regulated and down-regulated genes in the GO database with a P-value of at least 10⁻⁶ and a property size of 10. (Sample frequency) The proportion of the selected GO term within the GO annotated genes in the selected gene list; (background frequency) the proportion of the selected GO term within all GO annotated genes of the array; (Up in Δssb1Δssb2) the analysis was performed based on the list of up-regulated genes; (down in Δssb1Δssb2) analysis was based on the list of down-regulated genes. As an example, on the yeast 2.0 array, 4772 genes were annotated with GO terms. Of these, 201 contained the GO term “phosphorylation.” In the list of up-regulated genes, 179 had annotated GO terms, and “phosphorylation” was found 22 times.