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. 2009 Sep 1;23(17):2060–2075. doi: 10.1101/gad.543509

Figure 6.

Figure 6.

TRF1 deficiency leads to severe epidermal stem cell defects. (A) Percentage of Sox9-positive cells at interfollicular epidermis and at hair follicles of back skin sections from mice of the indicated genotypes. (Right) Representative images of Sox9 staining in E18.5 embryos and P6 mice. Arrows indicate Sox9 expression. (B) Percentage of cytokeratine 15 (K15)-positive cells in back skin sections from mice of the indicated genotypes. (Right) Representative images of K15-positive staining in the skin of P2 mice. Arrows indicate K15 expression. (C) Percentage of BrdU-positive cells in the interfollicular epidermis and in the hair follicles of back skin sections from mice of the indicated genotypes. (Right) Representative images of BrdU-positive staining in the skin of P1 mice. (D) Quantification of size and number of clones obtained. (Right) Representative examples of clones obtained from newborn mice (P1–P2) at the indicated dilutions. Clones are visualized by rhodamine stainning. n = mice analyzed per genotype. The total number of cells scored per genotype is indicated. Error bars indicate standard error. Students's t-test was used for statistical analysis and P-values are shown.