Skip to main content
. 2009 Sep 1;23(17):2076–2087. doi: 10.1101/gad.1788109

Figure 4.

Figure 4.

PLZF expands the human progenitor compartment in vivo. (A) Proportion of GFP+ cells within the total human CD45+ graft in the bone marrow (left) compared with Lin− CD34+ progenitor fraction (right) in a representative experiment 8 wk post-transplant. Bone marrow was pooled from four to eight mice, depleted of murine and mature human cells, and analyzed for GFP and CD34 expression by flow cytometry before and after lineage depletion. Equal percentage of GFP indicates equal contribution of transduced cells to mature and progenitor compartments, while increased or decreased proportion reflects expansion or depletion of progenitors relative to total cells. (B) Proportion of Lin− CD34+ progenitors and myeloid colony-forming units (CFU-G/M) within the total CD45+ graft in mice transplanted with PLZFKD or PLZFOX cells. Data are expressed as mean ± SEM of two independent experiments, each with Lin− cells isolated from four to eight engrafted mice.