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Endocrine fate is controlled by Notch2. Immunostaining for insulin (red) and EGFP (green) in phenotypically wild-type Ngn3-Cre, Ps1+/f; Ps2+/+; Z/EG mice and in Ngn3-Cre, Ps1+/f; Ps2+/+; Notch2+/f; Z/EG mice indicates that eliminating one copy of notch2 in Ngn3 progenitors can enhance the reduction in Presenilins and recapitulate the Pslow phenotype. Bars, 50 μm.
