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. 2009 Sep 15;23(18):2201–2209. doi: 10.1101/gad.1825809

Figure 2.

Figure 2.

Rev-erbα represses PGC-1α gene expression. (A) PGC-1α is required for Rev-erbα regulation of heme levels. HepG2 cells were infected with adenovirus expressing Rev-erbα shRNA and/or PGC-1α shRNA as indicated. Mean ± SEM is shown. (*) P < 0.05 versus control adenovirus. (B) Rev-erbα depletion induces PGC-1α. PGC-1α gene expression was measured after siRNA knockdown of either scrambled sequence (control) or human Rev-erbα in HepG2 liver cells. (C) Overexpression of Rev-erbα. Rev-erbα was determined by QPCR in mouse livers with tail-injected AAV-GFP (control) and AAV-Rev-erbα 55/59SD. (*) P < 0.05 versus control. (D) Rev-erbα represses PGC-1α expression. PGC-1α and Alas1 were measured in livers from mice transduced by tail injection of AAV-GFP (control) and AAV-Rev-erbα 55/59SD.