Figure 2.

miR profiling reveals dynamic regulation and illuminates immune cell infiltration in pretumor stages in RT2 carcinogenesis. (A) Fold changes of the three miR-17-92 clusters by chromosomal location in normal (N), hyperplastic (H), and angiogenic (A) islets, and tumors (T). Average plus standard deviation are shown with expression in normal islets normalized to 100. (B) Expression of miR-150, miR-142-3p, miR-142-5p, and miR-155 in the neoplastic stages. Average plus standard deviation are shown with expression in normal islets normalized to 100%. Supplemental Figure 2 documents the immune cell specificity of these miRs in this pathway.