Skip to main content
. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: FEBS J. 2009 Feb;276(4):995–1006. doi: 10.1111/j.1742-4658.2008.06836.x

Figure 1. Age-dependent changes in Aβ protofibril levels and total Aβ levels in tg-ArcSwe mice.

Figure 1

(A) Levels of protofibrils in nontransgenic (non-tg) and tg-ArcSwe mice at 2 (n=6), 4 (n=9), 10 (n=11), 14 (n=10) and 17 (n=6) months (mo) of age. Aβ protofibrils remained rather stable with age but increased approximately 50% from 10 to 14 months of age. (B) Total Aβ levels in the same set of mice increased dramatically after plaque onset, here represented by age groups of 10 months and older. (C) Aβ protofibrils as a fraction out of total Aβ (in %) was highest in young (4 mo) tg-ArcSwe mice and markedly decreased with age. (** P<0.01 and *** P<0.001, by one-way ANOVA and Tukey’s multiple comparison post hoc test).