Skip to main content
. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: FEBS J. 2009 Feb;276(4):995–1006. doi: 10.1111/j.1742-4658.2008.06836.x

Figure 3. Aβ protofibril levels in different APP transgenic models.

Figure 3

Aβ protofibrils in TBS-soluble cortical extracts from several APP transgenic mouse lines were measured with mAb158 protofibril ELISA. (A) Aβ protofibril levels were elevated in 2 months old tg2576 (n=7) and PSAPP (n=5) mice as compared to nontransgenic (non-tg) littermates (n=4), but were significantly lower than in age-matched tg-ArcSwe (n=6) mice. Aβ protofibril levels did not differ between young tg2576 and PSAPP mice. (B) Aβ protofibril levels were increased by more than 3-fold in cortical extracts (ctx) of 22–27 months old tg2576 (n=8) and PSAPP (n=5) mice. Cerebellar extracts (cer) from the same set of transgenic mice were essentially devoid of Aβ protofibrils, although a few tg2576 mice had measurable levels in the cerebellum. (** P<0.01 and *** P<0.001, by one-way ANOVA and Tukey’s multiple comparison post hoc test).