TABLE 2.
Microarray Screen of Alveolar Macrophages from HIV1+ Smokers for Expression of Matrix Metalloproteinases
| MMP genea | Expressedb | MMP gene | Expressedb |
|---|---|---|---|
| Collagenases | Elastases | ||
| MMP1 (interstitial collagenase, M10.001) | Yes | MMP12 (macrophage elastase, M10.009) | Yes |
| MMP8 (neutrophil collagenase, M10.002) | No | Membrane type MMPs | |
| MMP13 (collagenase-3, M10.013) | No | MMP14 (membrane type-1, MMP M10.014) | Yes |
| Gelatinases | MMP15 - membrane type 2 MMP M10.015 | No | |
| MMP2 (gelatinase A, M10.003) | Yes | MMP16 (membrane type 3, MMP M10.016) | No |
| MMP9 (gelatinase B, M10.004) | Yes | MMP17 (membrane type 4, MMP M10.017) | No |
| Stromelysins | MMP24 (membrane type 5, MMP3) | No | |
| MMP3 (stromelysin-1, progelatinase M10.005) | No | MMP25 (membrane type 6, MMP3) | No |
| MMP10 (stromelysin-2, M10.006) | Yes | Others | |
| MMP11 (stromelysin-3, M10.007) | No | MMP19 (rheumatoid arthritis inflamed synovium-1, M10.021) | No |
| Matrilysins | MMP23 (type II transmembrane MMP, M10.022) | No | |
| MMP7 (matrilysin-1, M10.008) | Yes | MMP21 (matrix metallopeptidase-21, M10.026) | No |
| MMP26 (matrilysin-2 M10.029) | No | MMP27 (matrix metallopeptidase-27)c | No |
| MMP28 (epilysin, M10.030) | No |
a
M10.0xx designations per MEROPS peptidase database v7.1 (27).
b
Present in >65% of the HIV1+ AM RNA samples.
c
Not present in MEROPS peptidase database v7.1.