Table 1.
Cytotoxicity of Vitexins. All cell lines, cultured with 10% FBS, were treated with EVn-50 (ranging from 0.05 to 20 µg/ml) or VB1 (50 nM to 30 µM) for 72 h. Cytotoxicy was measured by MTT assay. The IC50 values were determined by regression analysis. Data presented here are mean ± SEM of duplicate cultures from two separate experiments.
| Cell line | Cell type | Cytotoxicity IC50 | |
|---|---|---|---|
| EVn-50 (µg/ml) | VB-1 (µmol/L) | ||
| MCF-7 | Breast | 2.3 ± 0.19 | 3.2 ± 0.27 |
| ZR-75-1 | Breast | 0.95 ± 0.01 | 2.1 ± 0.15 |
| SK-BR-7 | Breast | 4.8 ± 0.24 | – |
| MDA-MB-435s | Breast | 2.1 ± 0.15 | – |
| MDA-MB-231 | Breast | 1.5 ± 0.11 | 1.8 ± 0.12 |
| LNCaP | Prostate | 1.3 ± 0.09 | – |
| PC-3 | Prostate | 0.8 ± 0.06 | – |
| COC1 | Ovarian | 0.25 ± .019 | 0.39 ± .023 |