Figure 3. The combination of cetuximab and BIBW-2992 induces tumor regressions of mouse lung tumors driven by EGFR^L858R+T790M.

(A) MRI images of lungs from a tumor-bearing C/L858R mouse pretreatment and after treatment with cetuximab for 2 weeks. H&E-stained section from treated C/L858R mouse (right panel) (original magnification, ×40). (B) MRI images of lungs from tumor-bearing C/L+T (top panels) and C/T790M (bottom panels) mice, pretreatment, after 6 days of erlotinib (erloti), and then after 4 weeks of cetuximab. H&E-stained section from treated C/L+T and C/T790M mice (right panels) (original magnification, ×40). (C) MRI images of lungs from tumor-bearing C/L+T and C/T790M mice, pretreatment, after treatment with either cetuximab for 2 weeks or BIBW-2992 for 2 weeks, and after treatment with cetuximab (cetux) and BIBW-2992 for 4 weeks. H&E-stained sections of lungs from mice treated with the drug combination (right panels) (original magnification, ×40). Representative images are shown from all studies.