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. 2009 Sep 8;119(10):2925–2941. doi: 10.1172/JCI38857

Figure 9. Importance of CaMKIIγ in renal tubular epithelial cell apoptosis and renal function in ER-stressed mice.

Figure 9

WT and Camk2g–/– mice were injected i.p. with 1 mg/kg tunicamycin or vehicle control. (A) The kidneys were harvested 48 hours later and stained using TUNEL (apoptosis) or DAPI (nuclei). Scale bar: 20 μm. Quantification of TUNEL-positive cells from 3 mice per group is shown. (B) Serum creatinine levels and urine albumin levels (normalized to urine creatinine) were determined for all groups of mice. Differing symbols indicate P < 0.01 (A) or P < 0.05 (B); identical symbols indicate differences that are not significant.