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. Author manuscript; available in PMC: 2009 Sep 25.
Published in final edited form as: J Cell Sci. 2008 Jul 29;121(Pt 16):2744–2750. doi: 10.1242/jcs.032482

Fig. 5.

Fig. 5

Mutants Δ2–8 and Δ9–21 did not produce conducting hemichannels, but coexpression of either one with wild-type CX37 inhibited currents produced from wild-type CX37. (A) Current-voltage relationships for control oocytes (×), wild-type CX37 (●), Δ2–8 (Δ) and differing ratios of Δ2–8 coexpressed with wild-type CX37 (□, 1:1; ◇, 0.2:1; ▽, 0.05:1). (B) Current-voltage relationships for wild-type CX37 (●), Δ9–21 (Δ), and differing ratios of Δ9–21 coexpressed with wild-type CX37 (□, 1:1; ◇, 0.2:1; ○, 0.1:1). (C,D) Graphs of mole fraction vs fractional current for Δ2–8 coexpressed with wild-type CX37 (C) and for Δ9–21 coexpressed with wild-type CX37 (D). Curves represent the theoretical values for inhibition by one (lower) or two (upper) mutant subunits within a hemichannel. Both Δ2–8 and Δ9–21 fit closely to the curve for inhibition of hemichannel function by one mutant subunit. Data are shown as mean ± s.e.m.