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. 2009 Oct 16;5(10):e1000533. doi: 10.1371/journal.pcbi.1000533

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The model with programmed expansion and contraction of latently infected cells can generate viral blips with reasonable amplitude and duration. , . Column A: . Activated latently infected cells divide about times over an interval [4],[6] days. No statistically significant decay of the latent reservoir is observed. Column B: . The latent reservoir decays at a very slow rate. This realization shows a half-life of months. Column C: . Activated cells divide about times over the same time interval. The latent reservoir decays more quickly than it does in B, corresponding to a half-life of roughly months. The other parameter values used are listed in Table 1. The blue horizontal line represents the detection limit of 50 RNA copies/mL.

Inline graphic — The model with programmed expansion and contraction of latently infected cells can generate viral blips with reasonable amplitude and duration. , . Column A: . Activated latently infected cells divide about times over an interval [4],[6] days. No statistically significant decay of the latent reservoir is observed. Column B: . The latent reservoir decays at a very slow rate. This realization shows a half-life of months. Column C: . Activated cells divide about times over the same time interval. The latent reservoir decays more quickly than it does in B, corresponding to a half-life of roughly months. The other parameter values used are listed in Table 1. The blue horizontal line represents the detection limit of 50 RNA copies/mL.