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. 2009 Oct 16;5(10):e1000533. doi: 10.1371/journal.pcbi.1000533

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The system is at steady state and at drug is applied. A, D, G and J: the latent reservoir size; B, E, H and K: viral load; C, F, I and L: the ratio of to , i.e., the relative contributions to the latent reservoir persistence from ongoing viral replication and latently infected cell proliferation. A, B and C: the carrying capacity of total latently infected cells is . We use different proliferation rates: (blue solid), (green dash-dotted), and (red dashed). The black solid line represents the detection limit. D, E and F: is fixed. Different carrying capacities of the total latently infected cells are used: (green dashed), (blue solid), (red dash-dotted). G, H and I: we use different fractions of infections that result in latency: (red dashed), (blue solid), and (black dotted). J, K and L: we use different drug efficacies: (red dashed), (blue solid), (black dotted). and the carrying capacity are fixed for the last two rows. The other parameter values used are listed in Table 1.

Inline graphic — The system is at steady state and at drug is applied. A, D, G and J: the latent reservoir size; B, E, H and K: viral load; C, F, I and L: the ratio of to , i.e., the relative contributions to the latent reservoir persistence from ongoing viral replication and latently infected cell proliferation. A, B and C: the carrying capacity of total latently infected cells is . We use different proliferation rates: (blue solid), (green dash-dotted), and (red dashed). The black solid line represents the detection limit. D, E and F: is fixed. Different carrying capacities of the total latently infected cells are used: (green dashed), (blue solid), (red dash-dotted). G, H and I: we use different fractions of infections that result in latency: (red dashed), (blue solid), and (black dotted). J, K and L: we use different drug efficacies: (red dashed), (blue solid), (black dotted). and the carrying capacity are fixed for the last two rows. The other parameter values used are listed in Table 1.