Figure 5.
Experiment 6: While Daun02 attenuated locomotor activity when cocaine was previously injected in the Paired environment (context A), Daun02 did not alter cocaine-induced locomotor activity on test day in c-fos-lacZ rats that were previously injected on induction day with cocaine in an alternate non-paired environment (context B) prior to Daun02 infusions. Cocaine-induced locomotion on test day was significantly higher than Day 1 for both context A and B groups infused with vehicle. Values are expressed as mean±SEM distance traveled during 1 h following test injections (n=10-15 for context A; n=17 for context B). * indicates a significant difference relative to that in rats infused with vehicle following cocaine injections on induction day.