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. Author manuscript; available in PMC: 2009 Sep 25.
Published in final edited form as: Sci Signal. 2009 Jul 21;2(80):ra35. doi: 10.1126/scisignal.2000369

Fig. 5. SIK1 links LKB1 to p53-dependent suppression of metastasis.

Fig. 5

(A) A549 cells expressing various versions of SIK1 with or without co-expression of shTP53 were subjected to Matrigel invasion assay. Mean ± SD for 3 independent experiments. (B) GFP-labeled A549 cells expressing various constructs as indicated were injected into tail veins of NOD/SCID mice and lung metastasis was assessed 6 weeks post injection. Representative fluorescence images of mouse lungs are shown. Lung metastasis burden was shown as indices pooled with each group of mice expressed as % (± SEM) over controls (n=6-9), * p < 0.001 (t-test). (C) Summary of LKB1-SIK1 pathway that mediates p53-dependent anoikis and suppresses metastasis.