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Buprenorphine blocked desensitization induced by etorphine. A, A control experiment showing the desensitization induced by etorphine (1 μm), the reversal of the current induced by naloxone (Nal; 1 μm), and the current induced by UK14304 (UK; 3 μm). B, An experiment done in a slice that was incubated in buprenorphine (5 nm, 1 h). The current induced by etorphine (1 μm) is significantly smaller and did not desensitize during the 10 min application period. Yoh, Yohimbine.
