Figure 6.

Chronic treatment of animals with buprenorphine. A, B, Representative experiments in slices taken from animals treated with a low (1 mg · kg⁻¹ · d⁻¹; A) or high (10 mg · kg⁻¹ · d⁻¹; B) dose of buprenorphine (BUP). A, In a slice taken from an animal treated with a low dose of buprenorphine (1 mg · kg⁻¹ · d⁻¹), desensitization and the recovery from desensitization is the same as that observed in untreated animals. B, Desensitization was completely blocked in slices taken from animals treated with a high dose. C, Summary of the peak current induced by ME (30 μm) in slices from control and buprenorphine-treated animals. D, Summary of the decline in the current induced by ME (30 μm) during a 10 min application. E, Summary of the recovery from desensitization induced by ME (30 μm, 10 min). The amount of recovery and the speed at which recovery occurred was increased in slices from buprenorphine-treated animals. The current induced by UK14304 (3 μm; UK) was reversed by the application of yohimbine (1 μm; YOH).