Table 2.

Patients Experiencing Acute Adverse Events

	WAI Regimen (n = 98)†					CIM Regimen (n = 99)†
	Grade					Grade
Adverse Event	0	1	2	3	4	0	1	2	3	4
Anemia	88	5	4	1	0	41	12	35	10	1
Gastrointestinal	33	33	21	8	3	37	33	19	8	2
Genitourinary	82	13	3	0	0	77	12	10	0	0
Renal	98	0	0	0	0	97	1	1	0	0
Hepatic	94	2	0	1	1	94	4	1	0	0
Fever	97	1	0	0	0	87	3	9	0	0
Infection	97	0	0	1	0	98	0	0	0	1*
Fatigue	92	5	0	1	0	77	13	6	2	1
Alopecia	98	0	0	0	0	54	12	33	0	0
Peripheral Neuropathy	97	1	0	0	0	87	6	4	2	0
Central Neuropathy	96	2	0	0	0	79	9	4	7	0
Allergy	98	0	0	0	0	95	2	2	0	0
Cutaneous	89	4	5	0	0	96	3	0	0	0
Cardiovascular	97	0	0	0	1	92	2	1	2	2
Pulmonary	97	0	1	0	0	93	3	3	0	0
Pain	94	2	2	0	0	86	9	3	1	0
Metabolic	97	1	0	0	0	90	2	2	3	2

Abbreviations: WAI, whole abdominal irradiation; CIM, cisplatin, ifosfamide with mesna chemotherapy.

^†Adverse events summarized for those who initiated study treatment.

^*One patient died of a systemic infection complicated by neutropenia which was attributed to CIM treatment.