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Schematic representation of the conversion mutation within the human trypsinogen gene family at the TCR-beta locus on chromosome 7q35. Each gene represents a tandem 10-kb repeat (Rowen et al., 1996). A region comprising parts of exon 2 and intron 2 of the PRSS1 acceptor gene is converted by the PRSS2 donor gene. The PRSS2 gene remains unaltered (adapted from Chen et al., 2001).
