Skip to main content
. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Nat Immunol. 2009 Aug 23;10(10):1073–1080. doi: 10.1038/ni.1782

Figure 8.

Figure 8

NOD2 is essential for host defense against virus infection. (a) IFN-β concentrations in the bronchoalveolar lavage (BAL) of RSV infected wild-type (WT) and NOD2-KO mice. Values (n=four mice per group) are mean ± s.e.m. P < .05, by t-test when data were normally distributed, or by Mann-Whitney Rank sum test when data were not normally distributed. (b) RSV titer in the BAL (3d post-infection) of WT and NOD2-KO mice. Values are mean ± s.e.m. P < .05, by t-test when data normally distributed, or by Mann- Whitney Rank sum test when data were not normally distributed. (c) H&E staining of lung sections obtained from RSV-infected WT and NOD2-KO mice. (d) Neutrophil sequestration in lungs of RSV infected (2d post-infection) WT and NOD2-KO mice was assessed by myeloperoxidase (MPO) activity assay with total lung homogenate. MPO activity is shown as percentage increase over enzyme activity in mock infected mice. Results are mean ± s.e., n=5, P < 0.05. (e) TUNEL staining of lung sections obtained from RSV infected WT and NOD2-KO mice. (f) Survival of WT and NOD2-KO mice infected with RSV (5×108 pfu per animal). P › 0.02 between NOD2-KO and WT mice as deduced by Wilcoxon test.