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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Brain Behav Immun. 2009 Jun 9;23(7):1028–1037. doi: 10.1016/j.bbi.2009.06.003

Figure 4.

Figure 4

(A) The suppression is ZAP70-dependent, βGBP did not affect ERK activity in ZAP70-deficient Jurkat cells (p116). However, the ability of βGBP to suppress ERK activity was restored in p116 that were retransfected with Zap70 (P116cl.39), which was as good as in w.t. Jurkat cells (E6.1). The cells were treated with 1 μg/ml βGBP for 3 hours. (B) βGBP at high doses (50 μg/ml) are cytotoxic for Jurkat cells, but not for TCR-deficient CEM or Zap70-deficient p116 cells. The viability was evaluated by Anexin V/PI staining. *P<0.05 is for comparisons with untreated cells.